I’ve definitely done the “leave it running overnight” thing with 1v7 extreme AI, but 256x tech. Yasama towers with +700 range and walk away.
Pretty sure I doubled my power bill for that month but I did get enough kills for the integer to roll over.
**edit:** just checked my screencaps, in my 256x meme days I broke the integer on trade profit and score but only managed to overflow the visible text field on kill count. That happens at 8 figures it looks like.
Yes, use infinite res for that.
Fun fact: resource stockpiles will display as a negative number when you overflow the value but score will reset to 0.